AACR-NCI-EORTC 2015
Epizyme scientists presented the following work at the 2015 Molecular Targets conference in Boston, Massachusetts. (Files are in .pdf format)
Tazemetostat:
- EZH2 plays a critical role in B-cell maturation and in non-Hodgkin’s lymphoma: Interplay between EZH2 function and B-cell activation
- Advanced Image Analysis of H3K27 Trimethylation in Skin from Subjects Dosed with the EZH2 Inhibitor Tazemetostat
- Chromatin flow cytometry based quantification of cell type specific alterations in histone methylation states resulting from in vitro and in vivo EZH2 inhibitor treatment
- Preclinical and clinical evaluation of EZH2 inhibitors in models of Small Cell Carcinoma of the Ovary, Hypercalcemic Type (SCCOHT)
- Physiologically-based pharmacokinetic modeling to support clinical investigation of the EZH2 inhibitor, tazemetostat (EPZ-6438) in INI1-deficient pediatric tumors
Pinometostat:
Research Platform: